Michelle Murrain received her B.A. in Natural Science and Mathematics from Bennington College, and her Ph.D. in Biology from Case Western Reserve University. She was an HIV/AIDS educator and advocate in the early part of the HIV epidemic in Cleveland, OH, and was part of training hotline workers that staffed the first statewide HIV/AIDS Information hotline. Michelle taught at Hampshire College from 1989 through 1999, as Assistant and Associate Professor of Biology. She conducted studies primarily on the AIDS epidemic, particularly as it affected women and people of color. She was also involved in AIDS education and advocacy during the first half of the 1990s. She was involved in several grant-funded projects to enhance in-service science education for teachers in the region, particularly in terms of use of technology in the classroom. She helped organize two conferences on technology in education, in 1998 and 1999. She first started to work with nonprofits and technology in 1996, when she assisted a local women's health organization with a Linux server that provided email and a website. That was also her introduction to open source software, which she has used consistently since that time.

Michelle has been involved in developing content and applications for the web, specifically for organizational, research and educational purposes, since 1994. In 1996, Michelle started a consulting practice that served the non-profit and educational sectors, primarily in the areas of developing database-driven web-sites, the implementation of Open Source software, and strategic technology planning. She has worked with a wide variety of nonprofit organizations, mostly in human services, women's health and education. From 2003 until 2005, she worked with Database Designs Associates , based in Boston, MA. She is a nationally recognized leader in the nonprofit technology field, and is the author of the NOSI Primer on Open Source Software. She is the coordinator of the Non Profit Open Source Initiative (NOSI), and was on the board of Aspiration , an organization that fosters software development in the nonprofit/NGO sector. She is presently on the board of NTEN , the Nonprofit Technology Network.

In 2005, Michelle took a sabbatical from nonprofit technology work to get her Certificate in Theological Studies at Pacific School of Religion in Berkeley, California. She created MetaCentric Technology Advising in 2007, after returning from sabbatical.

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